Paradoxical Normoxia-Dependent Selective Actions of Inorganic Nitrite in Human Muscular Conduit Arteries, and Related Selective Actions on Central Blood Pressures Running title: Omar et al.; Nitrite - Selective Dilator of Conduit Arteries

نویسندگان

  • Sami A Omar
  • Katharina D Tilgner
  • Joanne Hunt
  • Benyu Jiang
  • Paul Taylor
چکیده

1 1 K King's C Col olle le lege ge e L L Lon on o do do don n n Br Br Brit it itis is ish h He He Hear art t Fo Fo Foun n nda d t t tio o on C C Ce e e t nt ntr re r , , Ca Ca Card rd di io iova va vasc cular ar r D D Div iv ivis is isio io i n, n n, D D Dep ep ept t t o of of r r Cl Cl Clin in inic ical l P P Pha ha harm rm mac col olo og ogy y, y, Lo on ondo do d n, n, n, U U Un ni ite e ed d K K Kin ng ngdo do om m m; Abstract Background—Inorganic nitrite dilates small resistance arterioles, via hypoxia-facilitated

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Paradoxical normoxia-dependent selective actions of inorganic nitrite in human muscular conduit arteries and related selective actions on central blood pressures.

BACKGROUND Inorganic nitrite dilates small resistance arterioles via hypoxia-facilitated reduction to vasodilating nitric oxide. The effects of nitrite in human conduit arteries have not been investigated. In contrast to nitrite, organic nitrates are established selective dilators of conduit arteries. METHODS AND RESULTS We examined the effects of local and systemic administration of sodium n...

متن کامل

Hypoxic modulation of exogenous nitrite-induced vasodilation in humans.

BACKGROUND It has been proposed that under hypoxic conditions, nitrite may release nitric oxide, which causes potent vasodilation. We hypothesized that nitrite would have a greater dilator effect in capacitance than in resistance vessels because of lower oxygen tension and that resistance-vessel dilation should become more pronounced during hypoxemia. The effect of intra-arterial infusion of ni...

متن کامل

Regulation of vascular tone and pulse wave velocity in human muscular conduit arteries: selective effects of nitric oxide donors to dilate muscular arteries relative to resistance vessels.

Arterial tone in muscular conduit arteries may influence pressure wave reflection through changes in diameter and pulse wave velocity. We examined the relative specificity of vasodilator drugs for radial artery and forearm resistance vessels during intrabrachial arterial infusion. The nitric oxide (NO) donors, nitroglycerine and nitroprusside, and brain natriuretic peptide were compared with th...

متن کامل

CONTRACTIONS DUE TO α-ADRENOCEPTOR AGONISTS ARE MEDIATED BY α1-ADRENOCEPTORS IN RAT CAROTID ARTERY

Some large vessels have a mixed functional population of postjunctional α1- and α 2-adrenoceptors. The purpose of the work presented here was to investigate the population of postjunctional α -adrenoceptors in the rat isolated common carotid artelY Male Wi star rats were killed by overdose with pentobarbitone sodium, after which the left and right common carotid arteries were removed. Rings...

متن کامل

اثرات هیستو پاتولوژیکی نیتریت سدیم بر سرخرگ کلیوی موش صحرایی

Background and purpose: Nitrite is the material used in industry for storing food specially sausage and ham. Fast foods which contain high levels of nitrite are widely eaten throughout the world. Nitrite is also found in water, soil and ecosystem, and could highly influence human’s health. This study was performed to examine the histopathological effect of sodium nitrite on renal artery in rats...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:

دوره   شماره 

صفحات  -

تاریخ انتشار 2014